Population pharmacokinetics of artesunate and dihydroartemisinin in pregnant and non-pregnant women with malaria

@inproceedings{Morris2010PopulationPO,
  title={Population pharmacokinetics of artesunate and dihydroartemisinin in pregnant and non-pregnant women with malaria},
  author={Carrie Ann Morris and Marie A. Onyamboko and Edmund Capparelli and Matthew A. Koch and Joseph Atibu and Victor Lokomba and Macaya Douoguih and Jennifer J. Hemingway-Foday and David Wesche and Robert W Ryder and Carl L. Bose and Linda L. Wright and Antoinette Kitoto Tshefu and Steven Richard Meshnick and Lawrence L. Fleckenstein},
  booktitle={Malaria Journal},
  year={2010}
}
The World Health Organization endorses the use of artemisinin-based combination therapy for treatment of acute uncomplicated falciparum malaria in the second and third trimesters of pregnancy. However, the effects of pregnancy on the pharmacokinetics of artemisinin derivatives, such as artesunate (AS), are poorly understood. In this analysis, the population pharmacokinetics of oral AS, and its active metabolite dihydroartemisinin (DHA), were studied in pregnant and non-pregnant women at the… CONTINUE READING
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