Population pharmacokinetics of artemether and dihydroartemisinin following single intramuscular dosing of artemether in African children with severe falciparum malaria.

@article{Mithwani2003PopulationPO,
  title={Population pharmacokinetics of artemether and dihydroartemisinin following single intramuscular dosing of artemether in African children with severe falciparum malaria.},
  author={Sadik Mithwani and Leon Aarons and Gilbert O. Kokwaro and Oneeb Majid and Simon N. Muchohi and Geoffrey Edwards and Sumia Sir-Elkhatim Mohamed and Kevin Marsh and William Watkins},
  journal={British journal of clinical pharmacology},
  year={2003},
  volume={57 2},
  pages={
          146-52
        }
}
AIMS To determine the population pharmacokinetics of artemether and dihydroartemisinin in African children with severe malaria and acidosis associated with respiratory distress following an intramuscular injection of artemether. METHODS Following a single intramuscular (i.m.) injection of 3.2 mg kg-1 artemether, blood samples were withdrawn at various times over 24 h after the dose. Plasma was assayed for artemether and dihydroartemisinin by gas chromatography-mass spectrometry. The software… CONTINUE READING
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