Population pharmacokinetics of abacavir in plasma and cerebrospinal fluid.

@article{Capparelli2005PopulationPO,
  title={Population pharmacokinetics of abacavir in plasma and cerebrospinal fluid.},
  author={Edmund Capparelli and Scott L Letendre and Ronald J Ellis and Parul Parag Patel and Diane Holland and John McCutchan},
  journal={Antimicrobial agents and chemotherapy},
  year={2005},
  volume={49 6},
  pages={2504-6}
}
The distribution of abacavir into the cerebrospinal fluid (CSF) was assessed by use of a population pharmacokinetic analysis. Plasma and CSF abacavir concentrations in 54 subjects were determined. The abacavir CSF/plasma ratio averaged 36% and increased throughout the dose interval. Abacavir penetrates into the CSF in adequate concentrations to inhibit local human immunodeficiency virus replication.