Population pharmacokinetics and pharmacogenetics of imatinib in children and adults.

Abstract

PURPOSE The aim of this study was to explore the effect of several demographic, biological, and pharmacogenetic covariates on the disposition of imatinib and its main metabolite (CGP74588) in both adults and children. EXPERIMENTAL DESIGN Thirty-three children with solid malignancies included in a phase II exploratory study and 34 adults with… (More)
DOI: 10.1158/1078-0432.CCR-08-0950

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