Population pharmacokinetics and pharmacodynamics of thiopental: the effect of age revisited.

@article{Stanski1990PopulationPA,
  title={Population pharmacokinetics and pharmacodynamics of thiopental: the effect of age revisited.},
  author={Donald R. Stanski and Pierre O. Maitre},
  journal={Anesthesiology},
  year={1990},
  volume={72 3},
  pages={412-22}
}
The authors have previously attributed the mechanism for the 50-67% decrease in the required dose of thiopental for induction of anesthesia in aged human patients to a decrease in the initial distribution volume for thiopental. Using a larger group of patients and volunteers studied in the laboratory, the authors have re-examined thiopental pharmacokinetics and EEG pharmacodynamics relative to age. A population data analysis approach (NONMEM), using a three-compartment model, was used to… CONTINUE READING

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