Population pharmacokinetics and pharmacodynamics of piperacillin/tazobactam in patients with complicated intra-abdominal infection.

@article{Li2005PopulationPA,
  title={Population pharmacokinetics and pharmacodynamics of piperacillin/tazobactam in patients with complicated intra-abdominal infection.},
  author={Chonghua Li and Joseph Levente Kuti and Charles H. Nightingale and Debra L Mansfield and Adrian Dana and David P Nicolau},
  journal={The Journal of antimicrobial chemotherapy},
  year={2005},
  volume={56 2},
  pages={388-95}
}
OBJECTIVES We investigated the population pharmacokinetics and pharmacodynamics of piperacillin and tazobactam in hospitalized patients. PATIENTS AND METHODS A multicentre, randomized clinical trial was conducted in hospitalized patients with complicated intra-abdominal infection. Patients received piperacillin/tazobactam administered by either continuous infusion (13.5 g over 24 h, n = 130) or intermittent infusion (3.375 g every 6 h, n = 132). NONMEM was used to perform population… CONTINUE READING