Population pharmacokinetics and pharmacodynamics of busulfan with GSTA1 polymorphisms in patients undergoing allogeneic hematopoietic stem cell transplantation.

@article{Choi2015PopulationPA,
  title={Population pharmacokinetics and pharmacodynamics of busulfan with GSTA1 polymorphisms in patients undergoing allogeneic hematopoietic stem cell transplantation.},
  author={Boyoon Choi and Myeong Gyu Kim and Nayoung Han and Therasa Kim and Eunhee Ji and Seonyang Park and I W Kim and Jung Mi Oh},
  journal={Pharmacogenomics},
  year={2015},
  volume={16 14},
  pages={1585-94}
}
AIM A population pharmacokinetic (PPK) analysis was conducted to describe the influence of GSTA1 polymorphisms on intravenous busulfan in adults undergoing allogeneic hematopoietic stem cell transplantation. PATIENTS & METHODS A PPK model was developed from 36 patients by a one-compartment model with first-order elimination. RESULTS The typical value of clearance and volume of distribution were 11.0 l/h and 42.4 l, respectively. Clearance decreased by 15% and area under the concentration… CONTINUE READING