Population pharmacokinetics and exposure-response relationship of a muscarinic receptor antagonist, imidafenacin.

@article{Hasegawa2013PopulationPA,
  title={Population pharmacokinetics and exposure-response relationship of a muscarinic receptor antagonist, imidafenacin.},
  author={Chihiro Hasegawa and Tomoya Ohno and Susumu Nakade and Kimio Shibakawa and Hiroyuki Miyabe and Takafumi Ouchi and Mikio Ogawa},
  journal={Drug metabolism and pharmacokinetics},
  year={2013},
  volume={28 3},
  pages={
          203-12
        }
}
This study was designed to update the population pharmacokinetic model and investigate the exposure-response (efficacy and safety) and concentration-QT relationships for imidafenacin, a synthetic orally active muscarinic receptor antagonist. The population pharmacokinetic model was updated using data from 90 healthy subjects and 852 patients with an overactive bladder. Plasma concentration data from nine clinical studies were used, including new data from a long-term dose escalation study. The… CONTINUE READING

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