Population pharmacokinetics and bayesian estimator of cyclosporine in pediatric renal transplant patients.

@article{Irtan2007PopulationPA,
  title={Population pharmacokinetics and bayesian estimator of cyclosporine in pediatric renal transplant patients.},
  author={Sabine Irtan and Franck Saint-Marcoux and Annick Rousseau and Dong-tian Zhang and Val{\'e}riane Leroy and Pierre Marquet and Evelyne Jacqz-Aigrain},
  journal={Therapeutic drug monitoring},
  year={2007},
  volume={29 1},
  pages={96-102}
}
Cyclosporine A (CsA) is an immunosuppressive drug widely used in pediatric renal graft recipients. Its large interindividual pharmacokinetic variability and narrow therapeutic index render therapeutic drug monitoring necessary. However, information about CsA pharmacokinetics is scarce and no population pharmacokinetic (popPK) studies in these populations have been reported so far. to the objectives of this study were 1) to develop a PKpop model and identify the individual factors influencing… CONTINUE READING