Population pharmacokinetics/pharmacodynamics of docetaxel in phase II studies in patients with cancer.

@article{Bruno1998PopulationPO,
  title={Population pharmacokinetics/pharmacodynamics of docetaxel in phase II studies in patients with cancer.},
  author={R. Bruno and D. Hille and A. Riva and N. Vivier and W. W. ten Bokkel Huinnink and A. V. van Oosterom and S. Kaye and J. Verweij and F. Fossella and V. Valero and J. Rigas and A. Seidman and B. Chevallier and P. Fumoleau and H. Burris and P. Ravdin and L. Sheiner},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={1998},
  volume={16 1},
  pages={
          187-96
        }
}
  • R. Bruno, D. Hille, +14 authors L. Sheiner
  • Published 1998
  • Medicine
  • Journal of clinical oncology : official journal of the American Society of Clinical Oncology
PURPOSE The population pharmacokinetic/pharmacodynamic (PK/PD) approach was prospectively integrated in the clinical development of docetaxel to assess the PK profile in a large population of patients and investigate systemic exposure as a prognostic factor for clinical outcome. PATIENTS AND METHODS PK analysis was performed at first course in 24 phase II studies of docetaxel monotherapy using four randomized limited-sampling schedules. Bayesian estimates of clearance (CL), area under the… Expand
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