Population pharmacokinetic-pharmacodynamic analysis of fluindione in patients.


OBJECTIVE Fluindione is a vitamin K antagonist with a long half-life. This study was designed to investigate the pharmacokinetics and pharmacodynamics of multiple doses of fluindione in patients. METHODS In a learning group of 49 patients who began fluindione treatment, blood samples were taken 12, 18, or 24 hours after one, three, and five doses… (More)


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@article{Mentr1998PopulationPA, title={Population pharmacokinetic-pharmacodynamic analysis of fluindione in patients.}, author={France Mentr{\'e} and Françoise Pousset and Emmanuelle Comets and Beno{\^i}t Plaud and Bertrand Diquet and Gilles Montalescot and Annick Ankri and Alain Mallet and Philippe P Lechat}, journal={Clinical pharmacology and therapeutics}, year={1998}, volume={63 1}, pages={64-78} }