Population pharmacokinetic models of lamotrigine in different age groups of Chinese children with epilepsy

@article{Zhang2016PopulationPM,
  title={Population pharmacokinetic models of lamotrigine in different age groups of Chinese children with epilepsy},
  author={Zhong-bin Zhang and Shuang-min Ji and Ying Han and Li-li Zang and Ying-hui Wang and Wei Lu and Li Wang and Ye Wu},
  journal={European Journal of Clinical Pharmacology},
  year={2016},
  volume={73},
  pages={445-453}
}
The study aims to establish population pharmacokinetic (PPK) models of lamotrigine (LTG) in different age groups of epileptic children by nonlinear mixed effect modelling(NONMEM), and provide essential tools and theoretical basis for individualised optimal drug dose. Cases of 473 epileptic children were divided into infant, toddler and preschool age (≤6… CONTINUE READING