Population pharmacokinetic modelling of total and unbound cefazolin plasma concentrations as a guide for dosing in preterm and term neonates.

@article{Cock2014PopulationPM,
  title={Population pharmacokinetic modelling of total and unbound cefazolin plasma concentrations as a guide for dosing in preterm and term neonates.},
  author={Roosmarijn F. W. De Cock and Allan Smits and Karel Allegaert and Jn de Hoon and Veroniek S. M. Saegeman and Meindert Danhof and Catherijne A J Knibbe},
  journal={The Journal of antimicrobial chemotherapy},
  year={2014},
  volume={69 5},
  pages={
          1330-8
        }
}
OBJECTIVES Cefazolin is frequently administered for antimicrobial prophylaxis and treatment of infections. In neonates, pharmacokinetic observations are limited and dosing regimens variable. The aim of this study was to describe the pharmacokinetics of cefazolin in neonates based on total and unbound concentrations to optimize cefazolin dosing. METHODS Thirty-six neonates [median birth body weight 2720 (range 540-4200) g, current body weight (cBW) 2755 (830-4200) g and postnatal age (PNA) 9… CONTINUE READING

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