Population pharmacokinetic modeling in very premature infants receiving midazolam during mechanical ventilation: midazolam neonatal pharmacokinetics.

@article{Lee1999PopulationPM,
  title={Population pharmacokinetic modeling in very premature infants receiving midazolam during mechanical ventilation: midazolam neonatal pharmacokinetics.},
  author={Toong Chow Lee and Bruce G. Charles and G J Harte and Peter H. Gray and Peter A Steer and Vicki Flenady},
  journal={Anesthesiology},
  year={1999},
  volume={90 2},
  pages={451-7}
}
BACKGROUND Midazolam is used widely as a sedative to facilitate mechanical ventilation. This prospective study investigated the population pharmacokinetics of midazolam in very premature infants. METHODS Midazolam (100 microg/kg) was administered as a rapid intravenous bolus dose every 4-6 h to 60 very premature neonates with a mean (range) gestational age of 27 weeks (24-31 weeks), a birth weight of 965 g (523-1,470 g), and an age of 4.5 days (2-15 days). A median (range) of four (one to… CONTINUE READING