Population pharmacokinetic modeling and simulation for assessing renal impairment effect on the pharmacokinetics of mirogabalin.

Abstract

A population pharmacokinetic model was developed to describe plasma concentrations of mirogabalin and lactam metabolite, obtained following a single oral dose of 5 mg mirogabalin to subjects with varying degrees of renal function.A 2-compartment model was used for both mirogabalin and lactam metabolite. Body weight was a significant covariate on volume of… (More)
DOI: 10.1002/jcph.584

Topics

Cite this paper

@article{Yin2016PopulationPM, title={Population pharmacokinetic modeling and simulation for assessing renal impairment effect on the pharmacokinetics of mirogabalin.}, author={Ophelia Qi Ping Yin and Domenico Merante and Kenneth E. Truitt and Raymond O. Miller}, journal={Journal of clinical pharmacology}, year={2016}, volume={56 2}, pages={203-12} }