Population pharmacokinetic and pharmacogenomic analysis of tacrolimus in pediatric living-donor liver transplant recipients.

@article{Fukudo2006PopulationPA,
  title={Population pharmacokinetic and pharmacogenomic analysis of tacrolimus in pediatric living-donor liver transplant recipients.},
  author={Masahide Fukudo and Ikuko Yano and Satohiro Masuda and Maki Goto and Miwa Uesugi and Toshiya Katsura and Y. Ogura and Fumitaka Oike and Yasutsugu Takada and Hiroto Egawa and Shinji Uemoto and Ken-ichi Inui},
  journal={Clinical pharmacology and therapeutics},
  year={2006},
  volume={80 4},
  pages={331-45}
}
OBJECTIVE Our objective was to investigate the population pharmacokinetics of tacrolimus in pediatric living-donor liver transplant recipients and examine the effects of the multidrug resistance 1 (MDR1) gene and the cytochrome P450 (CYP) genes CYP3A4 and CYP3A5 on the oral clearance of tacrolimus. METHODS Data were collected retrospectively from 130 de novo pediatric liver transplant recipients treated with tacrolimus during the first 50 postoperative days. Pharmacogenomic data including… CONTINUE READING

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