Population pharmacokinetic and pharmacodynamic modeling of amodiaquine and desethylamodiaquine in women with Plasmodium vivax malaria during and after pregnancy.

@article{Tarning2012PopulationPA,
  title={Population pharmacokinetic and pharmacodynamic modeling of amodiaquine and desethylamodiaquine in women with Plasmodium vivax malaria during and after pregnancy.},
  author={Joel Tarning and Palang Chotsiri and Vincent Jullien and Marcus J Rijken and Martin Bergstrand and Mireille Cammas and Rose McGready and Pratap Singhasivanon and Nicholas P J Day and Nicholas J White and François H Nosten and Niklas Lindeg{\aa}rdh},
  journal={Antimicrobial agents and chemotherapy},
  year={2012},
  volume={56 11},
  pages={5764-73}
}
Amodiaquine is effective for the treatment of Plasmodium vivax malaria, but there is little information on the pharmacokinetic and pharmacodynamic properties of amodiaquine in pregnant women with malaria. This study evaluated the population pharmacokinetic and pharmacodynamic properties of amodiaquine and its biologically active metabolite, desethylamodiaquine, in pregnant women with P. vivax infection and again after delivery. Twenty-seven pregnant women infected with P. vivax malaria on the… CONTINUE READING
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1 Excerpt

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