Population pharmacokinetic and pharmacodynamic modelling of the antimalarial chemotherapy chlorproguanil/dapsone.

@article{Simpson2006PopulationPA,
  title={Population pharmacokinetic and pharmacodynamic modelling of the antimalarial chemotherapy chlorproguanil/dapsone.},
  author={Julie A Simpson and Dyfrig A Hughes and Christine Manyando and Kalifa A Bojang and Leon Aarons and Peter A. Winstanley and Geoffrey Edwards and William M. Watkins and Steve Ward},
  journal={British journal of clinical pharmacology},
  year={2006},
  volume={61 3},
  pages={289-300}
}
AIMS To determine the population pharmacokinetics of chlorproguanil, dapsone and the active metabolite of chlorproguanil, chlorcycloguanil; and to estimate the duration of parasitocidal activity for chlorpoguanil/dapsone against Plasmodium falciparum isolates of varying sensitivity. METHODS Rich and sparse pharmacokinetic data were collected prospectively from: healthy volunteers (n=48) and adults (n=65) and children (n=68) suffering from P. falciparum malaria. All subjects received 2.0 mg kg… CONTINUE READING