Population pharmacokinetic analysis of daikenchuto, a traditional Japanese medicine (Kampo) in Japanese and US health volunteers.

@article{Munekage2013PopulationPA,
  title={Population pharmacokinetic analysis of daikenchuto, a traditional Japanese medicine (Kampo) in Japanese and US health volunteers.},
  author={Masaya Munekage and Kengo Ichikawa and Hiroyuki Kitagawa and Kazuhisa Ishihara and Hideaki Uehara and Junko Watanabe and Toru Kono and Kazuhiro Hanazaki},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2013},
  volume={41 6},
  pages={1256-63}
}
We constructed population pharmacokinetic (PK) models for the five constituents of daikenchuto (DKT), a traditional Japanese herbal medicine. Data were collected from two randomized PK studies conducted in Japan and the United States. Participants received single oral doses of 2.5 g, 5 g, and 10 g of DKT. The plasma concentrations of five DKT constituents--hydroxy-α-sanshool (HAS), hydroxyl-β-sanshool (HBS), 6-shogaol (6S), 10-shogaol (10S), and ginsenoside Rb1 (GRB1)--were determined by liquid… CONTINUE READING

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