Population pharmacokinetic analysis for nelfinavir and its metabolite M8 in virologically controlled HIV-infected patients on HAART.

@article{Panhard2005PopulationPA,
  title={Population pharmacokinetic analysis for nelfinavir and its metabolite M8 in virologically controlled HIV-infected patients on HAART.},
  author={Xavi{\`e}re Panhard and C{\'e}cile Goujard and Mayeule Legrand and A. M. Taburet and Bertrand Diquet and France Mentr{\'e}},
  journal={British journal of clinical pharmacology},
  year={2005},
  volume={60 4},
  pages={390-403}
}
AIMS To describe the pharmacokinetics of nelfinavir and its main metabolite M8 in HIV-infected patients with a sustained virological response, to characterize the effect of covariates and to estimate inter- and intra-individual variability in the pharmacokinetics. METHODS Three hundred and twenty concentrations of both nelfinavir and M8 were measured in 46 patients enrolled in the COPHAR 1-ANRS 102 study. Blood samples were taken at a first visit (one sample before drug administration and… CONTINUE READING