Population pharmacodynamics and pharmacokinetics of remifentanil as a supplement to nitrous oxide anesthesia for elective abdominal surgery.

@article{Drover1998PopulationPA,
  title={Population pharmacodynamics and pharmacokinetics of remifentanil as a supplement to nitrous oxide anesthesia for elective abdominal surgery.},
  author={David R. Drover and H. J. M. Lemmens},
  journal={Anesthesiology},
  year={1998},
  volume={89 4},
  pages={
          869-77
        }
}
BACKGROUND Remifentanil blood concentrations necessary for adequate intraoperative anesthesia have not been defined. The goal of this study was to determine the blood concentrations of remifentanil needed for anesthesia with 66% nitrous oxide during intraabdominal surgery. In addition, the pharmacokinetics of remifentanil and the effects of covariates on both the pharmacodynamics and the pharmacokinetics were determined. METHODS Anesthesia was induced and maintained with 66% nitrous oxide in… CONTINUE READING
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