Population pharmacodynamic model for ketorolac analgesia.

  title={Population pharmacodynamic model for ketorolac analgesia.},
  author={Jaap W. Mandema and Donald R. Stanski},
  journal={Clinical pharmacology and therapeutics},
  volume={60 6},
OBJECTIVE To derive a population pharmacokinetic-pharmacodynamic model that characterizes the distribution of pain relief scores and remedication times observed in patients receiving intramuscular ketorolac for the treatment of moderate to severe postoperative pain. BACKGROUND The data analysis approach deals with the complexities of analyzing analgesic trial data: (1) repeated measurements, (2) ordered categorical response variables, and (3) nonrandom censoring because the patients can take… CONTINUE READING

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