Population history and its impact on medical genetics in Quebec

@article{Laberge2005PopulationHA,
  title={Population history and its impact on medical genetics in Quebec},
  author={A-M Laberge and J. Michaud and A. Richter and E. Lemyre and M. Lambert and B. Brais and G. Mitchell},
  journal={Clinical Genetics},
  year={2005},
  volume={68}
}
  • A-M Laberge, J. Michaud, +4 authors G. Mitchell
  • Published 2005
  • History, Medicine
  • Clinical Genetics
    • Knowledge of the genetic demography of Quebec is useful for gene mapping, diagnosis, treatment, community genetics and public health. The French‐Canadian population of Quebec, currently about 6 million people, descends from about 8500 French settlers who arrived in Nouvelle‐France between 1608 and 1759. The migrations of those settlers and their descendants led to a series of regional founder effects, reflected in the geographical distribution of genetic diseases in Quebec. This review… CONTINUE READING
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    References

    SHOWING 1-10 OF 154 REFERENCES
    Human genetics: lessons from Quebec populations.
    • C. Scriver
    • Medicine
    • Annual review of genomics and human genetics
    • 2001
    • 113
    Human Genetics: Lessons from Quebec Populations1
    • 102
    Variability of the genetic contribution of Quebec population founders associated to some deleterious genes.
    • 98
    Mutation profiles of phenylketonuria in Quebec populations: evidence of stratification and novel mutations.
    • 19
    The French Canadian Tay-Sachs disease deletion mutation: identification of probable founders
    • 21
    Geographic distribution and genealogy of mutation 207 of the lipoprotein lipase gene in the French Canadian population of Québec
    • 19
    Hereditary disorders in the French Canadian population of Quebec. II. Contribution of Perche.
    • 23
    Hereditary disorders in the French Canadian population of Quebec. I. In search of founders.
    • 38
    Cystic fibrosis mutations in North American populations of French ancestry: analysis of Quebec French-Canadian and Louisiana Acadian families.
    • 26
    • PDF
    Geographic distribution of 18 autosomal recessive disorders in the French Canadian population of Saguenay-Lac-Saint-Jean, Quebec.
    • 2
    • Highly Influential