Population genomics studies identify signatures of global dispersal and drug resistance in Plasmodium vivax

@article{Hupalo2016PopulationGS,
  title={Population genomics studies identify signatures of global dispersal and drug resistance in Plasmodium vivax},
  author={Daniel N. Hupalo and Zunping Luo and Alexandre I. Melnikov and Patrick Lee Sutton and Peter Rogov and Anan{\'i}as A. Escalante and Andr{\'e}s Felipe Hern{\'a}ndez Vallejo and S. Herrero Herrera and Myriam Ar{\'e}valo-Herrera and Qi Fan and Ying Wang and Liwang Cui and Carmen M. Lucas and Salom{\'o}n Durand and Juan Francisco Reyes S{\'a}nchez and G Christian Baldeviano and Andres G. Lescano and Moses Laman and C{\'e}line Barnadas and Alyssa E Barry and Ivo Mueller and James W. Kazura and Alex Eapen and D. Jayaprakash Kanagaraj and Neelamkumar Valecha and Marcelo U Ferreira and Wanlapa Roobsoong and Wang Nguitragool and Jetsumon Sattabonkot and Dionicia Gamboa and Margaret N. Kosek and Joseph M Vinetz and Lilia Gonz{\'a}lez-Cer{\'o}n and Bruce W. Birren and Daniel E. Neafsey and Jane M. Carlton},
  journal={Nature Genetics},
  year={2016},
  volume={48},
  pages={953-958}
}
Plasmodium vivax is a major public health burden, responsible for the majority of malaria infections outside Africa. We explored the impact of demographic history and selective pressures on the P. vivax genome by sequencing 182 clinical isolates sampled from 11 countries across the globe, using hybrid selection to overcome human DNA contamination. We confirmed previous reports of high genomic diversity in P. vivax relative to the more virulent Plasmodium falciparum species; regional populations… CONTINUE READING
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