Population genomic analysis of outcrossing and recombination in yeast

  title={Population genomic analysis of outcrossing and recombination in yeast},
  author={Douglas M. Ruderfer and Stephen C. Pratt and Hannah S. Seidel and Leonid Kruglyak},
  journal={Nature Genetics},
The budding yeast Saccharomyces cerevisiae has been used by humans for millennia to make wine, beer and bread. More recently, it became a key model organism for studies of eukaryotic biology and for genomic analysis. However, relatively little is known about the natural lifestyle and population genetics of yeast. One major question is whether genetically diverse yeast strains mate and recombine in the wild. We developed a method to infer the evolutionary history of a species from genome… 

Population genomics of domestic and wild yeasts

Rather than one or two domestication events leading to the extant baker’s yeasts, the population structure of S. cerevisiae consists of a few well-defined, geographically isolated lineages and many different mosaics of these lineages, supporting the idea that human influence provided the opportunity for cross-breeding and production of new combinations of pre-existing variations.

Population Genomics Reveals Chromosome-Scale Heterogeneous Evolution in a Protoploid Yeast

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Geographic Origin and Diversity of Wine Strains of Saccharomyces

  • L. Bisson
  • Biology
    American Journal of Enology and Viticulture
  • 2012
Comparative sequence analysis has refined the knowledge of yeast lineages and offers explanation for the evolution of phenotypic diversity observed in winery and vineyard populations.

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The baker’s yeast Saccharomyces cerevisiae has become a powerful model in ecology and evolutionary biology and exhibit hallmark differences in sexuality, heterozygosity, gene copy number variation, horizontal gene transfer and introgression events, and maltose utilization ability.

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A short history of recombination in yeast.




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Ecological and evolutionary genomics of Saccharomyces cerevisiae

It is shown not only that budding yeast is a prime model system to address fundamental molecular and cellular biology questions, but also that it is becoming a powerful model species for ecological and evolutionary genomics studies as well.

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Evolution and variation of the yeast (Saccharomyces) genome.

The role of the yeast Saccharomyces in the development of human societies including the use of this organism in the making of wine, bread, beer, and distilled beverages is described and the model of "genome renewal" is presented.

Human genome sequence variation and the influence of gene history, mutation and recombination

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