Population genetics of translational robustness.

@article{Wilke2006PopulationGO,
  title={Population genetics of translational robustness.},
  author={Claus O. Wilke and David Allan Drummond},
  journal={Genetics},
  year={2006},
  volume={173 1},
  pages={473-81}
}
Recent work has shown that expression level is the main predictor of a gene's evolutionary rate and that more highly expressed genes evolve slower. A possible explanation for this observation is selection for proteins that fold properly despite mistranslation, in short selection for translational robustness. Translational robustness leads to the somewhat… CONTINUE READING