Population genetics of the angiotensin-converting enzyme in Chinese.

  title={Population genetics of the angiotensin-converting enzyme in Chinese.},
  author={Edmund Lee},
  journal={British journal of clinical pharmacology},
  volume={37 2},
  • Edmund Lee
  • Published 1994 in British journal of clinical pharmacology
A genetic polymorphism exists for the angiotensin-converting enzyme (ACE) gene which accounts for 44% of the variance of circulating ACE activity in a normal Caucasian population. The presence or absence of a 250 bp fragment in intron 16 of the gene serves as a marker for this polymorphism. One hundred and eighty-nine normal Chinese subjects were genotyped and phenotyped for this ACE polymorphism. The frequencies of the deletion and insertion alleles among Chinese are 0.3 and 0.7 respectively… CONTINUE READING

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