Population genetics, pleiotropy, and the preferential fixation of mutations during adaptive evolution.

@article{Streisfeld2011PopulationGP,
  title={Population genetics, pleiotropy, and the preferential fixation of mutations during adaptive evolution.},
  author={Matthew A. Streisfeld and Mark Rausher},
  journal={Evolution; international journal of organic evolution},
  year={2011},
  volume={65 3},
  pages={629-42}
}
Ongoing debate centers on whether certain types of mutations are fixed preferentially during adaptive evolution. Although there has been much discussion, no quantitative framework currently exists to test for these biases. Here, we describe a method for distinguishing between the two processes that likely account for biased rates of substitution: variation in mutation rates and variation in the probability that a mutation becomes fixed once it arises. We then use this approach to examine the… CONTINUE READING

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