• DOI:10.1038/ng761
Corpus ID: 25627134

Population genetic structure of variable drug response

@article{Wilson2001PopulationGS,
  title={Population genetic structure of variable drug response},
  author={J. Wilson and M. Weale and A. Smith and F. Gratrix and B. Fletcher and Mark George Thomas and N. Bradman and D. Goldstein},
  journal={Nature Genetics},
  year={2001},
  volume={29},
  pages={265-269}
}

• J. Wilson, M. Weale, +5 authors D. Goldstein
• Published 2001
• Biology, Medicine
• Nature Genetics

Geographic patterns of genetic variation, including variation at drug metabolizing enzyme (DME) loci and drug targets, indicate that geographic structuring of inter-individual variation in drug response may occur frequently. This raises two questions: how to represent human population genetic structure in the evaluation of drug safety and efficacy, and how to relate this structure to drug response. We address these by (i) inferring the genetic structure present in a heterogeneous sample and (ii… Expand

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