Population genetic structure of variable drug response

@article{Wilson2001PopulationGS,
  title={Population genetic structure of variable drug response},
  author={J. Wilson and M. Weale and A. Smith and F. Gratrix and B. Fletcher and Mark George Thomas and N. Bradman and D. Goldstein},
  journal={Nature Genetics},
  year={2001},
  volume={29},
  pages={265-269}
}
Geographic patterns of genetic variation, including variation at drug metabolizing enzyme (DME) loci and drug targets, indicate that geographic structuring of inter-individual variation in drug response may occur frequently. This raises two questions: how to represent human population genetic structure in the evaluation of drug safety and efficacy, and how to relate this structure to drug response. We address these by (i) inferring the genetic structure present in a heterogeneous sample and (ii… Expand
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References

SHOWING 1-10 OF 21 REFERENCES
Molecular mechanisms of genetic polymorphisms of drug metabolism.
Inference of population structure using multilocus genotype data.
Optimization of cytochrome P4502D6 (CYP2D6) phenotype assignment using a genotyping algorithm based on allele frequency data.
Molecular mechanism of slow acetylation of drugs and carcinogens in humans.
Identification of the primary gene defect at the cytochrome P450 CYP2D locus
Consistent long-range linkage disequilibrium generated by admixture in a Bantu-Semitic hybrid population.
Multiple mutations of the human cytochrome P450IID6 gene (CYP2D6) in poor metabolizers of debrisoquine. Study of the functional significance of individual mutations by expression of chimeric genes.
Genetic evidence for a higher female migration rate in humans
Genetic tests which identify the principal defects in CYP2C19 responsible for the polymorphism in mephenytoin metabolism.
A new genetic defect in human CYP2C19: mutation of the initiation codon is responsible for poor metabolism of S-mephenytoin.
...
1
2
3
...