Population genetic structure of variable drug response

  title={Population genetic structure of variable drug response},
  author={James F. Wilson and Michael E. Weale and Alice Smith and Fiona Gratrix and Benjamin Fletcher and Mark George Thomas and Neil N Bradman and David B. Goldstein},
  journal={Nature Genetics},
Geographic patterns of genetic variation, including variation at drug metabolizing enzyme (DME) loci and drug targets, indicate that geographic structuring of inter-individual variation in drug response may occur frequently. This raises two questions: how to represent human population genetic structure in the evaluation of drug safety and efficacy, and how to relate this structure to drug response. We address these by (i) inferring the genetic structure present in a heterogeneous sample and (ii… 

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