Population genetic diversity of the NAT2 gene supports a role of acetylation in human adaptation to farming in Central Asia

@article{Magalon2008PopulationGD,
  title={Population genetic diversity of the NAT2 gene supports a role of acetylation in human adaptation to farming in Central Asia},
  author={H{\'e}l{\`e}ne Magalon and Etienne Patin and Frederic Austerlitz and Tatyana Hegay and Almaz A. Aldashev and Llu{\'i}s Quintana-Murci and Evelyne Heyer},
  journal={European Journal of Human Genetics},
  year={2008},
  volume={16},
  pages={243-251}
}
The arylamine N-acetyltransferase 2 (NAT2) enzyme detoxifies a wide spectrum of naturally occurring xenobiotics including carcinogens and drugs. Variation at the NAT2 gene has been linked to the human acetylation capacity, either ‘slow’ or ‘fast’, which modifies susceptibility to cancer and adverse drug reactions. We investigated the possible influence of natural selection in shaping the acetylation phenotype and the NAT2 gene variability in six Central Asian populations, who are either long… CONTINUE READING