Population genetic correlates of declining transmission in a human pathogen

@inproceedings{Nkhoma2013PopulationGC,
  title={Population genetic correlates of declining transmission in a human pathogen},
  author={Standwell C Nkhoma and Shalini K. Nair and Salma Al-Saai and Elizabeth A Ashley and Rose M McGready and Aung Pyae Phyo and François Nosten and Tim Anderson},
  booktitle={Molecular ecology},
  year={2013}
}
Pathogen control programs provide a valuable, but rarely exploited, opportunity to directly examine the relationship between population decline and population genetics. We investigated the impact of an ~12-fold decline in transmission on the population genetics of Plasmodium falciparum infections (n = 1731) sampled from four clinics on the Thai-Burma border over 10 years and genotyped using 96 genome-wide SNPs. The most striking associated genetic change was a reduction in the frequency of… CONTINUE READING
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