Population estimate of people with clinical Alzheimer's disease and mild cognitive impairment in the United States (2020–2060)

@article{Rajan2021PopulationEO,
  title={Population estimate of people with clinical Alzheimer's disease and mild cognitive impairment in the United States (2020–2060)},
  author={Kumar B Rajan and Jennifer Weuve and Lisa L. Barnes and Elizabeth A McAninch and Robert S. Wilson and Denis A. Evans},
  journal={Alzheimer's \& Dementia},
  year={2021},
  volume={17},
  pages={1966 - 1975}
}
  • K. Rajan, J. Weuve, +3 authors Denis A. Evans
  • Published 27 May 2021
  • Medicine
  • Alzheimer's & Dementia
The estimate of people with clinical Alzheimer's disease (AD) and mild cognitive impairment provides an understanding of the disease burden. 
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References

SHOWING 1-10 OF 54 REFERENCES
Forecasting the prevalence of preclinical and clinical Alzheimer's disease in the United States
We forecast the prevalence of preclinical and clinical Alzheimer's disease (AD) and evaluated potential impacts of primary and secondary preventions in the United States.
The worldwide costs of dementia 2015 and comparisons with 2010
In 2010, Alzheimer's Disease International presented estimates of the global cost of illness (COI) of dementia. Since then, new studies have been conducted, and the number of people with dementia has
Direct medical costs and source of cost differences across the spectrum of cognitive decline: A population-based study
Objective cost estimates and source of cost differences are needed across the spectrum of cognition, including cognitively normal (CN), mild cognitive impairment (MCI), newly discovered dementia, and
Clinical diagnosis of Alzheimer's disease: Report of the NINCDS—ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
Article abstract-Clinical criteria for the diagnosis of Alzheimer’s disease include insidious onset and progressive impairment of memory and other cognitive functions. There are no motor, sensory, or
Age-specific incidence of Alzheimer's disease in a community population.
TLDR
The incidence of Alzheimer's disease is substantial and is approximately 14 times higher among persons older than 85 years compared with those between 65 and 69 years of age.
Prevalence of dementia in a southern European population in two different time periods: the ZARADEMP Project
TLDR
The prevalence of dementia in two different time periods and two different studies is compared to find out whether the disease is more common in adults over a longer period of time or a shorter time period.
Trends in the incidence and prevalence of Alzheimer’s disease, dementia, and cognitive impairment in the United States
TLDR
Although some decline was observed in the Minnesota cohort, no statistically significant trends were apparent in the community studies, and a significant reduction in cognitive impairment measured by neuropsychological testing was identified in the national survey.
Alzheimer disease in the United States (2010–2050) estimated using the 2010 census
TLDR
The number of people in the United States with AD dementia will increase dramatically in the next 40 years unless preventive measures are developed.
The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease
TLDR
The workgroup sought to ensure that the revised criteria would be flexible enough to be used by both general healthcare providers without access to neuropsychological testing, advanced imaging, and cerebrospinal fluid measures, and specialized investigators involved in research or in clinical trial studies who would have these tools available.
Use of brief cognitive tests to identify individuals in the community with clinically diagnosed Alzheimer's disease.
TLDR
The results showed that the EBMT was better at enriching the population of the poor performance group with persons who had Alzheimer's disease (AD), and had a lower refusal rate among non-proxy respondents than the SPMSQ.
...
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5
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