Population dynamics of rapid fixation in cytotoxic T lymphocyte escape mutants of influenza A.

@article{Gog2003PopulationDO,
  title={Population dynamics of rapid fixation in cytotoxic T lymphocyte escape mutants of influenza A.},
  author={Julia R. Gog and G F Rimmelzwaan and Albert D M E Osterhaus and Bryan T. Grenfell},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 19},
  pages={11143-7}
}
The dynamics of cellular immunity against pathogens, and its interaction with the human MHC system, is a key area for empirical research, both within individual hosts and in population genetic surveys. However, in contrast with humoral immunity, the dynamics of cellular immunity have not been modeled at the population level. Here, we address this lacuna with a model of recently observed dramatic invasions of cytotoxic T lymphocyte escape mutants in human influenza A. In particular, we offer an… CONTINUE READING

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