Population dynamics of islet-infiltrating cells in autoimmune diabetes.

  title={Population dynamics of islet-infiltrating cells in autoimmune diabetes.},
  author={Angela M Magnuson and Greg M Thurber and Rainer H Kohler and Ralph Weissleder and Diane Mathis and Christophe Benoist},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={112 5},
Type-1 diabetes in the nonobese diabetic (NOD) mouse starts with an insulitis stage, wherein a mixed population of leukocytes invades the pancreas, followed by overt diabetes once enough insulin-producing β-cells are destroyed by invading immunocytes. Little is known of the dynamics of lymphocyte movement into the pancreas during disease progression. We… CONTINUE READING