Population dynamics of an RNA virus and its defective interfering particles in passage cultures

Abstract

Viruses can fall prey to their defective interfering (DI) particles. When viruses are cultured by serial passage on susceptible host cells, the presence of virus-like DI particles can cause virus populations to rise and fall, reflecting predator-prey interactions between DI and virus particles. The levels of virus and DI particles in each population passage… (More)
DOI: 10.1186/1743-422X-7-257

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