Population distribution and ancestry of the cancer protective MDM2 SNP285 (rs117039649)

@inproceedings{Knappskog2014PopulationDA,
  title={Population distribution and ancestry of the cancer protective MDM2 SNP285 (rs117039649)},
  author={Stian Knappskog and Liv Beathe Gansmo and Khadizha Dibirova and Andres Metspalu and Cezary Cybulski and Paolo Peterlongo and Lauri A. Aaltonen and Lars J Vatten and P{\aa}l Richard Romundstad and Kristian Hveem and Peter Devilee and Gareth D. Evans and Dongxin Lin and Guy Van Camp and Vangelis G. Manolopoulos and Ana Osorio and Lili Milani and Tayfun Ozcelik and Pierre A. Zalloua and Francis Mouzaya and Elena A Bliznetz and Elena V Balanovska and Elvira Pocheshkova and Vaidutis Ku{\vc}inskas and Lubov Atramentova and Pagbajabyn Nymadawa and Konstantin Titov and Maria Lavryashina and Yuldash Yusupov and Natalia Valerijevna Bogdanova and Sergey Koshel and Jorge Zamora and David C. Wedge and Deborah Charlesworth and Thilo D{\"o}rk and O Balanovsky and P E L{\o}nning},
  booktitle={Oncotarget},
  year={2014}
}
The MDM2 promoter SNP285C is located on the SNP309G allele. While SNP309G enhances Sp1 transcription factor binding and MDM2 transcription, SNP285C antagonizes Sp1 binding and reduces the risk of breast-, ovary- and endometrial cancer. Assessing SNP285 and 309 genotypes across 25 different ethnic populations (>10.000 individuals), the incidence of SNP285C was 6-8% across European populations except for Finns (1.2%) and Saami (0.3%). The incidence decreased towards the Middle-East and Eastern… CONTINUE READING

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SHOWING 1-10 OF 16 CITATIONS

APOBEC3A/B deletion polymorphism and cancer risk

  • Carcinogenesis
  • 2018
VIEW 6 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Influence of MDM2 SNP309 and SNP285 status on the risk of cancer in the breast, prostate, lung and colon.

  • International journal of cancer
  • 2015
VIEW 5 EXCERPTS
CITES RESULTS, METHODS & BACKGROUND
HIGHLY INFLUENCED

References

Publications referenced by this paper.
SHOWING 1-10 OF 45 REFERENCES

DNA analysis of an early modern human from Tianyuan Cave, China.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2013
VIEW 1 EXCERPT

Effect of the MDM2 promoter polymorphisms SNP309T>G and SNP285G>C on the risk of ovarian cancer in BRCA1 mutation carriers

M Bjornslett, S Knappskog, PE Lonning, A. Dorum
  • BMC Cancer
  • 2012

MDM 2 promoter SNP 344 T > A ( rs 1196333 ) status does not affect cancer risk

S Knappskog, LB Gansmo, +12 authors PE Lonning
  • PLoS One
  • 2012

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