Population differences in the testosterone levels of young men are associated with prostate cancer disparities in older men

  title={Population differences in the testosterone levels of young men are associated with prostate cancer disparities in older men},
  author={Louis Calistro Alvarado},
  journal={American Journal of Human Biology},
Although there is evidence that greater exposure to testosterone is associated with an increased risk of prostate cancer, a recent analysis of 18 prospective studies found no relationship between levels of endogenous sex hormones and prostate cancer development. However, the reviewed studies were subject to methodological constraints that would obscure any potential relationship between prostate cancer and androgenic hormones. If prostate cancer risk is mediated by lifetime exposure to… Expand
Associations between Testosterone Levels and Incident Prostate, Lung, and Colorectal Cancer. A Population-Based Study
Higher free testosterone was associated with incident prostate cancer, and higher testosterone levels may also be associated with lung cancer, though SHBG and LH were not. Expand
Do evolutionary life-history trade-offs influence prostate cancer risk? a review of population variation in testosterone levels and prostate cancer disparities
  • L. Alvarado
  • Biology, Medicine
  • Evolutionary applications
  • 2013
It is hypothesized that Westernized men in aggressive social environments, characterized by intense male–male competition, will further augment testosterone production aggravating prostate cancer risk. Expand
Evidence for low androgenicity among Indian (South Asian) men
The data suggest that men from the Indian subcontinent are smaller, manifest lower levels of circulating free testosterone, lower mean PSA levels and lean body mass, but are comparable to white Caucasian men in terms of SHBG, estradiol, levels of visceral fat and CAG repeat length. Expand
Prostate Cancer Disparities throughout the Cancer Control Continuum
An objective of this paper is to provide a comprehensive summary of the racial disparities found at each stage of the PCa Care Continuum which includes prevention, detection, treatments, and outcomes and survival. Expand
Male Subfertility and Prostate Cancer Risk: Epidemiological and Genetic Studies
The hypothesis that alterations in sex steroid action, potentially via interaction with the AHR-ARNT signaling pathway, may contribute to the overall reduction in PCa risk in subfertile men is supported. Expand
Interactions among genes, tumor biology and the environment in cancer health disparities: examining the evidence on a national and global scale.
The magnitude and causes of global cancer health disparities are discussed, and the evidence that genetic and tumor biological factors contribute to existing cancer incidence and outcome differences among population groups in the USA is evaluated. Expand
Genetically predicted testosterone and cardiovascular risk factors in men: a Mendelian randomization analysis in the Guangzhou Biobank Cohort Study.
The findings did not corroborate observed protective effects of testosterone on cardiovascular risk factors or risk of ischaemic heart disease among men, but raises the possibility that higher testosterone may be associated with an unhealthier lipid profile. Expand
A cross-sectional study of the association of age, race and ethnicity, and body mass index with sex steroid hormone marker profiles among men in the National Health and Nutrition Examination Survey (NHANES III)
The associations of sex steroid hormone profiles by race/ethnicity are novel, while the findings by age and BMI groups are largely consistent with observations from single hormone studies. Expand
Testosterone concentrations in young healthy us versus Chinese men
The aim of the present study is to examine the differences in total, free, and bioavailable testosterone concentrations between healthy young men from the United States and from the most economically developed part of China, i.e., Hong Kong. Expand
Human reproduction and health: an evolutionary perspective
An evolutionary perspective on reproductive biology could improve the efficacy of public health efforts to reduce the risk of hormone-sensitive cancers and other non-communicable diseases. Expand