Population differences in SLE susceptibility genes: STAT4 and BLK, but not PXK, are associated with systemic lupus erythematosus in Hong Kong Chinese

@article{Yang2009PopulationDI,
  title={Population differences in SLE susceptibility genes: STAT4 and BLK, but not PXK, are associated with systemic lupus erythematosus in Hong Kong Chinese},
  author={W. L. Yang and P. K.-M. Ng and M Zhao and Nattiya Hirankarn and C.S. Lau and C. C. Mok and T. M. Chan and Raymond Woon Sing Wong and K W Lee and M.Y. Mok and S. N. Wong and Yingyos Avihingsanon and T. L. Lee and M H-K Ho and P P W Lee and Wilfred Hing Sang Wong and Yu-Lung Lau},
  journal={Genes and Immunity},
  year={2009},
  volume={10},
  pages={219-226}
}
In this study, we compared the association of several newly discovered susceptibility genes for systemic lupus erythematosus (SLE) between populations of European origin and two Asian populations. Using 910 SLE patients and 1440 healthy controls from Chinese living in Hong Kong, and 278 SLE patients and 383 controls in Thailand, we studied association of STAT4, BLK and PXK with the disease. Our data confirmed association of STAT4 (rs7574865, odds ratio (OR) =1.71, P=3.55 × 10−23) and BLK… 

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Title Genome-wide association study in asian populations identifies variants in ETS 1 and WDFY 4 associated with systemic lupus erythematosus

A genome-wide association study in Asian Populations identifies genetic variants in ETS1 and WDFY4 associated with Systemic Lupus Erythematosus and confirmed association of the HLA locus, STAT4, TNFSF4, BLK, BANK1, IRF5, and TNFAIP3 with SLE in Asians.

A meta-analysis of the association of STAT4 polymorphism with systemic lupus erythematosus

The results do support STAT4 rs7574865 polymorphism as a susceptibility factor for SLE in populations of European and Asian origin and suggest thatSTAT4 rs7601754 polymorphism might be associated with SLE risk.

Polymorphism in STAT4 Increase the Risk of Systemic Lupus Erythematosus: An Updated Meta-Analysis

The results do support STAT4 rs7574865 polymorphism as a susceptibility factor for SLE in populations of different ethnic and that its prevalence is ethnicity dependent.
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