Population differences in DNA sequence variation and linkage disequilibrium at the PON1 gene.

@article{Koda2004PopulationDI,
  title={Population differences in DNA sequence variation and linkage disequilibrium at the PON1 gene.},
  author={Yoshiro Koda and Hidenori Tachida and Mikiko Soejima and Osamu Takenaka and Hiroshi Kimura},
  journal={Annals of human genetics},
  year={2004},
  volume={68 Pt 2},
  pages={110-9}
}
Polymorphisms of the promoter region (-108C/T) and the coding region (192Q/R) of the paraoxonase 1 gene (PON1) showed differences in association with cardiovascular disease risk in various populations. To characterize the genetic variation underlying these important polymorphisms, we examined DNA sequence variation both in a 1.3-kb promoter region 16.5 kb from codon 192, and in a 1.7-kb region centered on the 192Q/R polymorphic site of the coding region of PON1, in 30 Africans, 30 Europeans and… CONTINUE READING

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