Population-based studies reveal differences in the allelic frequencies of two functionally significant human interleukin-4 receptor polymorphisms in several ethnic groups

@article{Caggana1999PopulationbasedSR,
  title={Population-based studies reveal differences in the allelic frequencies of two functionally significant human interleukin-4 receptor polymorphisms in several ethnic groups},
  author={Michele Caggana and Kimberly L Walker and A. A. Reilly and James M. Conroy and Salvatore J Duva and Anne C. Walsh},
  journal={Genetics in Medicine},
  year={1999},
  volume={1},
  pages={267-271}
}
Purpose: The presence of functionally significant human interleukin-4 receptor sequence variants, GIn551Arg and 11e50Val, was examined in four anonymous New York State populations defined by ethnic origin. These variants were studied because they are associated with atopy or atopic asthma whose prevalence varies in different populations.Methods: PCR/RFLP (11e50Val) and PCR/allele-specific oligonucleotide hybridization (GIn551Arg) assays were developed to detect both polymorphisms in 855 newborn… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 10 extracted citations

Pathogenicity of a disease-associated human IL-4 receptor allele in experimental asthma

The Journal of experimental medicine • 2009
View 4 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 31 references

, Sheppard D , Mohra M . Donaldaon DD , Locksley RM , Corry DB Requ ~ rement for IL - 13 Independently of 1 L - 4 In experimental asthma

E Baker, SA Whitmore, +5 authors P Beckman
Scrence • 1998

Cuttmg edge : Effects of an allergy - assoc ~ ated mutatlon In the human IL - 4 Ra ( Q 576 Ri on human IL - 4 - induced signal transduct ~ on

HY Ydng, AD Keegan
Hum Molrc Gcnct • 1998

Ile 50 Val variant of IL - 4 Ra upregulates IgE synthesis and associates rnth atopic asthma

T Murata, 1 Taguchi, RK Puri
Nnt Genet • 1998

Interleuk ~ n13 receptor a ' but not a chain : a functional component of interleukin - 4 receptors :

B Miloux, P Laurent, +3 authors P VitaN.Ferrara
Blood • 1998

Linkage and de l i c association of atopy and markers flanking the IL 4 - receptor gene

Hershey GIT, MF Fnedrich, LA Esswein, ML Thomas, TA Chatila
Clin Exp Allergy • 1998

Llnkage of chromosome 5 q and 1 l q gene markers to asthma - associated quantitative traits in Australian chddren

DS Postma, ER Bleecker
Am J Resprr C r ~ t Cnre Med • 1998

Luylmbazl I . Xu X . Schotield B . Neben n . Karp CL

M Warnock, AE Wakll, F Brombacher, DM Rennick
Interleukin - 13 : Central med ~ ator of allerg ~ c asthma Sclence • 1998

Murray R , Grenc ~ s R , McKenzle AN lmpa ~ red development of T , 2 cells in 1 ~ - 13 - deficient mice

M Wills-Karp
Immunrty • 1998

Rdpid , e f i c ~ en t method for multiplex ampl ~ fica - tion from filter paper

RA Fisher
Hum Alrltat • 1998

Similar Papers

Loading similar papers…