Population-based family studies in genetic epidemiology

@article{Hopper2005PopulationbasedFS,
  title={Population-based family studies in genetic epidemiology},
  author={John L. Hopper and D Timothy Bishop and Douglas F. Easton},
  journal={The Lancet},
  year={2005},
  volume={366},
  pages={1397-1406}
}
Designs that involve families (the traditional strength of genetic epidemiology) and population-based sampling (the traditional strength of environmental epidemiology) allow investigation of both genes and environment, separately or together, and allow valid inference to the population. These case-control-family designs (including those involving twin pairs), can be regarded as retrospective cohort studies of relatives, and can be used for: determining familial risks and genetic models… CONTINUE READING
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