Population-based family history-specific risks for colorectal cancer: a constellation approach.

  title={Population-based family history-specific risks for colorectal cancer: a constellation approach.},
  author={David P. Taylor and Randall W. Burt and Marc S. Williams and Peter J. Haug and Lisa Anne Cannon-Albright},
  volume={138 3},
BACKGROUND & AIMS Colorectal cancer (CRC) risk estimates based on family history typically include only close relatives. We report familial relative risk (FRR) in probands with various combinations, or constellations, of affected relatives, extending to third-degree. METHODS A population-based resource that includes a computerized genealogy linked to statewide cancer records was used to identify genetic relationships among CRC cases and their first-, second-, and third-degree relatives (FDRs… 
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Risk prediction derived from specific and extended family history allows identification of women at highest risk and could be a powerful, efficient tool to individualize cancer prevention and screening.
Increased Risk of Colorectal Cancer Among Family Members of All Ages, Regardless of Age of Index Case at Diagnosis.
  • N. Samadder, Ken R. Smith, K. Curtin
  • Medicine
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
  • 2015
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This study represents a unique comprehensive population-based study of familial cancer and will be useful in generating hypotheses about specific genetic and environmental factors that can be tested in genetic linkage and case-control studies.
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It is suggested that LOB has a heritable component and may represent a genetically homogeneous form of BC, and Pedigrees with excess LOB may be useful in isolating additional BC predisposition genes.
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A family history of colorectal cancer is associated with an increased risk of the disease, especially among younger people, and the risk decreased with increasing age.
Familial colorectal adenocarcinoma from the Swedish family‐cancer database
The data suggest that HNPCC is the largest single disease entity among CRCs, probably accounting for less than 50% of familial CRC, and other familial components appear heterogeneous, characterized by incomplete penetrance, recessive mode of inheritance and few associated tumor sites.
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A casecontrol family study to assess risk for colorectal cancer in relatives and to define possible markers for any increased risk, using a matched casecontrol design.
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Familiality of cancer in Utah.
The Utah Population Database allows examination of the genetic relationships among the 35.7% of all cancer cases in the state that have genealogical records. Familial clustering of cancer is measured