Population-based family history-specific risks for colorectal cancer: a constellation approach.

@article{Taylor2010PopulationbasedFH,
  title={Population-based family history-specific risks for colorectal cancer: a constellation approach.},
  author={David P. Taylor and Randall W. Burt and Marc S. Williams and Peter J. Haug and Lisa Anne Cannon-Albright},
  journal={Gastroenterology},
  year={2010},
  volume={138 3},
  pages={
          877-85
        }
}
BACKGROUND & AIMS Colorectal cancer (CRC) risk estimates based on family history typically include only close relatives. We report familial relative risk (FRR) in probands with various combinations, or constellations, of affected relatives, extending to third-degree. METHODS A population-based resource that includes a computerized genealogy linked to statewide cancer records was used to identify genetic relationships among CRC cases and their first-, second-, and third-degree relatives (FDRs… 
Population-based relative risks for specific family history constellations of breast cancer
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Risk prediction derived from the specific and extended family history constellation of affected relatives allows identification of females at increased risk even when they do not have a conventionally defined high-risk family; these risks could be a powerful, efficient tool to individualize cancer screening and prevention.
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TLDR
Risk prediction derived from specific and extended family history allows identification of women at highest risk and could be a powerful, efficient tool to individualize cancer prevention and screening.
Increased Risk of Colorectal Cancer Among Family Members of All Ages, Regardless of Age of Index Case at Diagnosis.
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Effects of Family History on Relative and Absolute Risks for Colorectal Cancer: a Systematic Review and Meta-Analysis.
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TLDR
Evidence based findings provide novel information to help to identify people at high risk with a family history of colorectal cancer that can potentially be used for risk adapted screening.
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TLDR
Current colorectal cancer screening guidelines from Australia, New Zealand, Canada, the US, and UK are reviewed and it is claimed that these guidelines are not sufficiently precise for a large proportion of people within these categories.
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TLDR
Irrespective of their FH status, persons with history of colonoscopy had a lower CRC risk compared with persons without previous colonoscopies and without family history, and adjusting for previous Colonoscopy is crucial for deriving valid estimates of FH‐related CRC risk.
A new colorectal cancer risk prediction model incorporating family history, personal and environmental factors
TLDR
The FRP-based model provided better risk-prediction and discrimination than the FH-based models, and a detailed family history may be useful for targeted risk-based screening and clinical management.
Use of Family History and Genetic Testing to Determine Risk of Colorectal Cancer.
TLDR
Determination of CRC risk based on family cancer history and results of genetic testing can provide a personalized approach to cancer screening and prevention, with optimal use of colonoscopy to effectively decrease CRC incidence and mortality.
Calculating Starting Age for Screening in Relatives of Patients With Colorectal Cancer Based on Data From Large Nationwide Datasets.
TLDR
Risk-adapted starting ages of CRC screening for close or distant relatives of patients with CRC are determined, using high-quality nationwide datasets in Sweden and might be used in counselling individuals about the appropriate age to start CRC screening.
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