Population-based detection of Lynch syndrome in young colorectal cancer patients using microsatellite instability as the initial test.


Approximately 1-2% of colorectal cancers (CRC) arise because of germline mutations in DNA mismatch repair genes, referred to as Lynch syndrome. These tumours show microsatellite instability (MSI) and loss of expression of mismatch repair proteins. Pre-symptomatic identification of mutation carriers has been demonstrated to improve survival; however, there… (More)
DOI: 10.1002/ijc.23863