Population and familial association between the D4 dopamine receptor gene and measures of Novelty Seeking

@article{Benjamin1996PopulationAF,
  title={Population and familial association between the D4 dopamine receptor gene and measures of Novelty Seeking},
  author={Jonathan Benjamin and Lin Li and Chavis Patterson and Benjamin D. Greenberg and Dennis L. Murphy and Dean Hamer},
  journal={Nature Genetics},
  year={1996},
  volume={12},
  pages={81-84}
}
Twin and adoption studies suggest that 30 to 60% of the variance in many personality traits is due to inherited factors. However, there is little knowledge of the number or identity of the responsible genes, how they differ between individuals, or how their gene products interact with the developing brain and with environmental and experiential factors to generate the complex blend of attitudes and actions that comprise human temperament1. In the accompanying paper, Ebstein et al.2 have found a… Expand

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Genes for personality traits: implications for psychopathology.
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In methodically similar but independent studies of 124 Israeli and 315 American normal volunteers, an association was found between the dopamine D4 receptor gene (D4DR) and the personality trait of novelty-seeking and the 5-HTT polymorphism was associated with anxiety- and depression-related personality traits. Expand
Lack of Association between Polymorphisms of the Dopamine D4 Receptor Gene and Personality
TLDR
The data do not provide evidence for a role of DRD4 exon III and the –521C/T polymorphism in the modulation of novelty seeking and extraversion, and these findings are in line with several earlier studies which have failed to replicate the initial association results. Expand
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TLDR
No significant associations were observed between novelty-seeking or positive emotional experience and these D4DR polymorphisms, which seems unlikely to represent measurement or genetic differences across studies, although environmental differences may be possible. Expand
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  • 2004
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TLDR
Comparisons were made between selected MPQ traits measuring the affective dimension (negative affectivity, stress reaction, alienation, and well-being) and evidence favoring linkage between the D2 and D4 receptor loci and these MPZ traits is found, with stronger evidence being seen for the D 2 polymorphisms. Expand
Association Between Novelty Seeking and Dopamine Receptor D4 (DRD4) Exon III Polymorphism
In 1996, Ebstein et al. and Benjamin et al. reported significant associations between the long repeat allele of DRD4 exon III and novelty seeking, which is a personality dimension postulated byExpand
An association between dopamine D4 receptor and transporter gene polymorphisms and personality traits, assessed using NEO-FFI in a Polish female population
Abstract We looked for an association between the DRD4 exon III and 3′UTR DAT1 polymorphisms and the personality traits of 200 unrelated young women of Polish descent. Personality traits wereExpand
The association between the serotonin and dopamine neurotransmitters and personality traits
TLDR
The main aims are to highlight that the study of candidate genes provides a fruitful ground for the identification of the biological underpinnings of personality without, though, reaching a general consensus about the strength of this relationship, and to outline that the research in personality genetics should be expanded to provide a clearer picture of the heritability of personality traits. Expand
Association between novelty seeking and the type 4 dopamine receptor gene in a large Finnish cohort sample.
TLDR
The results confirm the original findings of an association between the type 4 dopamine receptor (DRD4) gene and novelty seeking, while showing that novelty seeking is probably not influenced by the polymorphism itself but, rather, a different DNA variant in the DRD4 gene or another gene in linkage disequilibrium with it. Expand
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