Population analysis of the pharmacokinetics and the haematological toxicity of the fluorouracil-epirubicin-cyclophosphamide regimen in breast cancer patients

@article{Sandstrm2005PopulationAO,
  title={Population analysis of the pharmacokinetics and the haematological toxicity of the fluorouracil-epirubicin-cyclophosphamide regimen in breast cancer patients},
  author={Marie Sandstr{\"o}m and Henrik Lindman and P. -{\AA}. Nygren and Mats Johansson and Jonas Bergh and Mats O. Karlsson},
  journal={Cancer Chemotherapy and Pharmacology},
  year={2005},
  volume={58},
  pages={143-156}
}
Purpose: The aims of the study were (a) to characterise the pharmacokinetics (PK), including inter-individual variability (IIV) and inter-occasion variability (IOV) as well as covariate relationships and (b) to characterise the relationship between the PK and the haematological toxicity of the component drugs of the fluorouracil (5-FU)—epirubicin (EPI)—cyclophosphamide (CP) regimen in breast cancer patients. Patients and methods: Data from 140 breast cancer patients, either within one of… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 25 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 47 references

Similar Papers

Loading similar papers…