Population analysis of the non-linear red blood cell partitioning of draflazine following various infusion durations

@article{Snoeck1997PopulationAO,
  title={Population analysis of the non-linear red blood cell partitioning of draflazine following various infusion durations},
  author={Eric Snoeck and Vladimir K. Piotrovskij and Philippe Jacqmin and Robert L. Lins and Achiel van Peer and Meindert Danhof and R. J. H. Woestenborghs and Renilt van Gool and Alain G. Dupont and Joseph Heykants},
  journal={European Journal of Clinical Pharmacology},
  year={1997},
  volume={53},
  pages={57-63}
}
Objective: The pharmacokinetics and non-linear red blood cell partitioning of the nucleoside transport inhibitor draflazine were investigated in 19 healthy male and female subjects (age range 22–55 years) after a 15-min i.v. infusion of 1 mg, immediately followed by infusions of variable rates (0.25, 0.5 and 1 mg · h−1) and variable duration (2–24 h… CONTINUE READING