Population analysis of the non linear red blood cell partitioning and the concentration-effect relationship of draflazine following various infusion rates.

Abstract

AIMS To investigate the impact of the specific red blood cell binding on the pharmacokinetics and pharmacodynamics of the nucleoside transport inhibitor draflazine after i.v. administration at various infusion rates. It was also aimed to relate the red blood cell (RBC) occupancy of draflazine to the ex vivo measured adenosine breakdown inhibition (ABI… (More)

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@article{Snoeck1997PopulationAO, title={Population analysis of the non linear red blood cell partitioning and the concentration-effect relationship of draflazine following various infusion rates.}, author={Etienne Snoeck and Vladimir K. Piotrovskij and Philippe Jacqmin and Achiel Van Peer and Meindert Danhof and Kris Ver Donck and R. J. H. Woestenborghs and H A van Belle and Lucas M Van Bortel and Ronald van Gool and Aymeric Dupont and Jozef J. P. Heykants}, journal={British journal of clinical pharmacology}, year={1997}, volume={43 6}, pages={603-12} }