Population analysis of a 24-h paclitaxel infusion in advanced endometrial cancer: a gynaecological oncology group study.

@article{Mould2006PopulationAO,
  title={Population analysis of a 24-h paclitaxel infusion in advanced endometrial cancer: a gynaecological oncology group study.},
  author={Diane R Mould and Gini F. Fleming and Kathleen M. Darcy and David S. Spriggs},
  journal={British journal of clinical pharmacology},
  year={2006},
  volume={62 1},
  pages={56-70}
}
AIMS To examine determinants of paclitaxel disposition and the association between paclitaxel exposure and toxicity or survival in patients with advanced stage or recurrent endometrial cancer treated with doxorubicin plus paclitaxel. METHODS A limited sampling scheme was used to examine the population pharmacokinetics of paclitaxel in 160 patients from one arm of a randomized Phase III trial of doxorubicin plus paclitaxel or cisplatin. Four plasma samples per patient were collected at… CONTINUE READING