Population Substructure and Control Selection in Genome-Wide Association Studies

  title={Population Substructure and Control Selection in Genome-Wide Association Studies},
  author={Kai Yu and Zhaoming Wang and Qizhai Li and Sholom Wacholder and David J. Hunter and Robert Nathaniel Hoover and Stephen K Chanock and Gilles Thomas},
  journal={PLoS ONE},
  pages={645 - 649}
Determination of the relevance of both demanding classical epidemiologic criteria for control selection and robust handling of population stratification (PS) represents a major challenge in the design and analysis of genome-wide association studies (GWAS). Empirical data from two GWAS in European Americans of the Cancer Genetic Markers of Susceptibility (CGEMS) project were used to evaluate the impact of PS in studies with different control selection strategies. In each of the two original case… CONTINUE READING
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Genome - wide association study of 14 , 000 cases of seven common diseases and 3 , 000 shared controls

  • G Thomas, KB Jacobs, M Yeager, P Kraft, S Wacholder
  • Nature
  • 2007

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