Population Pharmacokinetics of Vancomycin in Postoperative Neurosurgical Patients and the Application in Dosing Recommendation.

Abstract

Our previous study indicates that cerebrospinal fluid (CSF) albumin level is a determinant of CSF vancomycin concentration for postoperative neurosurgical patients. We aimed to develop an improved vancomycin population pharmacokinetic model with incorporation of more covariates, and to provide dosing guidance for clinicians. Vancomycin was administered… (More)
DOI: 10.1016/j.xphs.2016.08.012

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Cite this paper

@article{Li2016PopulationPO, title={Population Pharmacokinetics of Vancomycin in Postoperative Neurosurgical Patients and the Application in Dosing Recommendation.}, author={Xingang Li and Yuanxing Esther Wu and Shusen Sun and Zhigang Zhao and Qiang Wang}, journal={Journal of pharmaceutical sciences}, year={2016}, volume={105 11}, pages={3425-3431} }